These approaches are not optimal for children and adolescents with disease and disability. Current exercise testing protocols were based on studies of athletes and high performing healthy individuals and were designed to test limits of performance at very high-intensity, unphysiological, maximal effort. The challenge is to determine what constitutes safe and beneficial level of physical activity when the underlying disease or condition imposes physiological constraints on exercise that are not present in otherwise healthy children. Like otherwise healthy children, children with chronic diseases and disabilities want to be physically active. A major challenge to improve both the immediate and long term care and health of such children has been the gap in our understanding of how to assess the biological effects of exercise. There is an increasing number of children who, through medical advances, now survive diseases and conditions that were once fatal, but which remain chronic and debilitating. The project is a collaboration among three major NIH Clinical Translational Science Awardees: 1) UCI (lead site with its affiliate CHOC), 2) Northwestern University (with its affiliate Lurie Children's Hospital), and 3) USC (with its affiliate Children's Hospital of Los Angeles).
This study is a cooperative investigation funded by the NIH.
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